Institut des Sciences Cardiovasculaires

L’Institut des Sciences Cardiovasculaires regroupe 33 équipes de recherche fondamentale et translationnelle d’excellence au sein d'Université Paris Cité afin de répondre aux grands enjeux et défis de la recherche cardiovasculaire. 

Si vous souhaitez effectuer un stage de Licence, de Master 1 ou 2 dans un de nos laboratoires, merci de contacter directement les responsables des équipes de recherche listées ci-dessous.

Le stage d’une durée de 44 jours sera non gratifié. Pour un stage dont la durée est supérieure, gratification se fera alors selon le tarif en vigueur (3,90 € par heure). L’étudiant(e) sera couvert(e) par une convention de stage, quelle qu’en soit sa durée.

Postdoctoral position available in Autophagy, cell biology and renal physiology

A two years postdoctoral position is available for a highly motivated Ph.D to work on the role of autophagy in kidney epithelial cell homeostasis. Our lab is currently interested in the mechanisms by which autophagy integrates fluid shear stress in kidney epithelial cells (for example of our recent publication on the subject see: Orhon et al 2016 Nat Cell Biol 18, 657-67; Miceli C et al, Nat Cell Biol., 2020, 22:1091-1102, Boukhalfa A, et al. Nat Commun. Jan 15 2020;11(1):294. To carry out this project, biochemical, cellular and microfluidic approaches will be implemented in the laboratory as well as in vivo animal (mouse and zebrafish) models and human tissue samples in collaboration with the Necker Hospital. Candidates with a Ph.D in molecular and cellular biology or in physiology obtained during the past four years and with experience in the fields of autophagy, cell signaling, kidney physiology, zebrafish model (not mandatory) are encouraged to apply. 

The position is available starting on January 1st, 2024 (the salary is in accordance with Inserm guidelines). The host team is part of the Cell Biology Department of the Institut Necker-Enfants Malades (INEM), created in January 2014. INEM is an international biomedical research center located on the Necker campus (downtown Paris), and supported by the INSERM, CNRS, and the Paris Cité University. The Necker campus encompasses as well the Hospital Necker-Enfants Malades (one of the main nephrology centers in France) and the Imagine Institute, devoted to genetic diseases study. Moreover, the Necker campus and INEM benefit from several core facilities (animal facility together with an aquatic zone devoted to zebrafish, histology, flow cytometry, imaging, genomics, bioinformatics, proteomics, viral production and metabolomics). 

https://www.institut-necker-enfants-malades.fr/index.php 

https://www.researchgate.net/institution/Institut_Necker_Enfants-Malades

Please send a concise cover letter with statement of research interest and summary of previous research activity, detailed curriculum vitae and two reference letters to Nicolas Dupont, INEM INSERM U1151, 156 Rue de Vaugirard - 75015, Paris Cedex 14, France.

Contact: nicolas.dupont@inserm.fr

Two research positions on Therapeutic EVs at Icahn School of Medicine at Mount Sinai, New York

One Postdoctoral Research Scientist and one Research Associate (RA) positions are available immediately in the “Exosomes and Epitranscriptome Laboratory” of Dr. Susmita Sahoo, at the Icahn School of Medicine at Mount Sinai, New York, NY.

Research in Sahoo Lab:

Dr. Sahoo’s laboratory conducts research in the field of genomic medicine, cardiac regeneration, gene therapy and heart failure to investigate molecular signaling, pathophysiology and therapeutics. Current positions involve pre-clinical, translational and basic science research on ‘EV-AAVs in Cardiac Gene Therapy”, which is a continuation of our research recently published in Circulation (https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.063759). Research in our lab involve tissue and organ communication, gene therapy and epitranscriptomic mechanisms to study heart failure. We use several state of the art technologies including for isolation and characterization of  extracellular vesicles (EVs), in vitro and in vivo therapeutic testing, molecular mechanisms of EV-mediated pathogenesis, biomarkers, therapeutic approaches, cardiac targeting, imaging flow cytometry (imagestream), electron, super-resolution and confocal microscopy, virus-based gene deliveries, stable-isotope-labeling mass spectrometry (SILAC), mass-spectrometry, in vitro and in vivo imaging, live imaging and small (rats and mice) and large animal (pig) models to address scientific questions in an innovative way.

More information about our research and researchers can be found here:

http://labs.icahn.mssm.edu/sahoolab/

http://labs.icahn.mssm.edu/sahoolab/job-openings/

Job Summary:

The Postdoctoral Research Fellow will lead the EV-AAV research project funded by Evox Therapeutics (https://www.evoxtherapeutics.com/) related to our Circulation article described above. The project involves AAV and EV-AAV isolation and characterization, therapeutic testing in vitro and in mice and investigating the cardiotropic mechanisms. The RA position will be involved in isolation of AAVs, EVs, and several molecular techniques associated with the projects. The positions will involve processing human, swine and rodent tissue specimens, contributing to several laboratory activities and working with other members of the team.

Requirements:

For the Postdoc position, preferences would be given to candidates experienced with Viral biology and/or EV biology and techniques, study of in vitro and in vivo mechanisms, mouse models, viruses, bioengineering and nanotechnology and with good publication records. For the RA position, preference would be given to candidates with prior experience in molecular biology or virology research. We are looking for independent, self-motivated individuals with excellent verbal and written communication skills with a PhD or MD/PhD in Biotechnology/Molecular Biology (for the postdoc position) and with a Bachelors/Masters/PhD degree (for the RA position). The appointment will include a competitive salary and benefits (including Mount Sinai discounted housing for postdocs in NYC), a dynamic multi-disciplinary research environment with access to the Institute’s state-of-the-art facilities that includes in vitro and in vivo imaging, flow cytometry and small and large animal surgical laboratories. 

Interested individuals should send their curriculum vitae containing a summary of past accomplishments, a statement of future objectives and names of professional referees by e-mail to susmita.sahoo@mssm.edu

About Us: The Cardiovascular Research Institute at the Icahn School of Medicine at Mount Sinai (https://icahn.mssm.edu/research/cardiovascular) is an interdisciplinary research center focused on both basic and translational research in genomics medicine, systems physiology, gene therapy, stem cell research, tissue regeneration, immunology, exosomes biology and electrophysiology.

Open Position Group leader - cardiac tissue engineering

The CNIC Cardiovascular Regeneration Program is recruiting a Group leader at an early career stage (Assistant/Associate Professor level) in the field of cardiac tissue engineering. The new Group Leader will establish a competitive research program in human cardiovascular tissue engineering and develop projects in one or various of the following areas: modelling cardiovascular physiology and pathology in vitro; establishment of cardiac repair/regeneration in vitro models; therapeutic use of in vitro generated cardiac cell lineages or engineered tissues.

CNIC offers integration in a highly competitive and stimulating environment in one of the largest institutions in the world dedicated to Cardiovascular Research. State-of-the-art facilities for basic and translational Cardiovascular Research and financial support will be available to the new group.

Apply here: https://www.cnic.es/en/convocatoria/group-leader-early-career-stage-assistantassociate-professor-level-field-cardiovascular

Open PhD Position in Neurovascular Biology

We are looking for a PhD student with interest in the field of Vascular Biology and Immunology. Candidates are interested in working in an interdisciplinary, translational team of biologists and clinician-scientists.

Our lab’s research interest focuses on understanding how different cells within the neurovascular niche communicate with each other during cerebral angiogenesis, blood-brain- barrier damage and repair, balancing vascular plasticity and quiescence, and angiocrine activation of the immune system. The Charité Universitätsmedizin Berlin offers a unique research landscape with many prestigious research institutions such as the BIH, MDC, DRFZ, and Neurocure cluster.

The PhD candidate should have a Master’s degree in the field of the life sciences and a special interest in vascular biology and/or immunology. To this end, the PhD will learn and apply advanced imaging and molecular biology, studying the interactions of vascular and immune interface in rare causes of stroke such as subarachnoid hemorrhage and Moyamoya disease.

The PhD candidate will be funded for 3 years by the German Research Foundation (DFG), and support to extramural funds will be provided. The PhD student will be co-mentored by a biologist and physician-scientist, overseen by Prof. Peter Vajkoczy.

Pease send your application including CV and references no later than September 11 to Dr. Ran Xu (ran.xu@charite.de) and Dr. Anja Nitzsche (anja.nitzsche@charite.de).

Post-Doctorat - Healthy longevity gene inspired therapy to rescue cardiovascular disease in progeria, University of Bristol – Bristol Heart Institute, United Kingdom

Contact: Prof Paolo Madeddu

mdprm@bristol.ac.uk or madeddu@yahoo.com

mobile (0)7961 720 574

Call for a Senior Research Associate Grade J 38 position at the University of Bristol – Bristol Heart Institute. The 2-year project grant is supported by the Medical Research Council and must start before 1st July 2022.

Job Family: Senior Research Associate

Grade/Pathway: Pathway 2 – Grade J

Salary range: £38,587 - £43,434

Hours of work: 35 hrs

Contract type: Open ended with funding for 24 months

Work pattern: Full Time

Vacancy Reference Number: Grant R102523-101

Post-doctorat - Cardioimmunology - Wurzburg, Germany

Lancement de l’appel à projet Début janvier 2022

Réception des dossiers complets 8 mars 2022 avant 17h

Sélection des experts et des référents scientifiques pour l’analyse des dossiers Mi-mars

Expertise externe des projets Fin mars – fin mai

Audition des candidats par le jury Juin

Envoi des résultats des projets de recherche aux candidats par mail

Début du Poste d’accueil au sein du laboratoire d’accueil 1er novembre 2022

Date limite de soumission du dossier : jeudi 08 mars 2022 avant 17h